风湿热儿血浆内皮素及降钙素基因相关肽的变化及其临床意义

Changes and clinical significance of plasma endothelin and calcitonin gene-related peptide in children with rheumatic fever

目的探讨风湿热心脏炎患儿血浆内皮素（ET）及降钙素基因相关肽（CGRP）的临床意义。方法用放射免疫法测定19例风湿热心脏炎患儿及21的健康儿童血浆ET及CGRP。结果患儿治疗前血浆ET升高而CGRP降低，心功能好转后分别回降及回升。心功能Ⅲ、Ⅳ级和心功能Ⅰ、Ⅱ级患儿及对照组儿童血浆ET逐渐降低，差异均有显著性；而CGRP却逐渐升高，但后两组的比较差异无显著。治疗前患儿ET与CGRP水平成直线负相关（γ=0．68，P＜0．01）。结论血浆ET及CGRP可作为风湿热心脏炎患儿心功能状态的监测指标。

To research the clinical significanece of plasma endothelin (ET) and calcitonin gene-related peptide(CGRP) in children with rheumatic fever carditis.Method Plasma ET and CGRP were determined by radioimmunoassy in 19 cases of rheumatic fever carditis and 21 healthy children.Results Plasma ET was increased and CGRP decreased before treatment and those were decreased and increased respectively after improvement of heart function. ET was getting lower and lower (heart function normal<heart functionⅢ, Ⅳ class < I, Ⅱclass,P<0. 05 and 0. 01) and CGRP higher and higher (the two groups of later had no obvious difference) along with the improvement of heart function. The levels of ET and CGRP showed linear negative correlation(γ=-0. 68,P<0. 01 ).Contlusiou The levels of plasma ET and CGRP may be regarded as a monitoring index of judging the condition of heart function in the children with rheumatic fever carditis.