儿童狼疮性肾炎的性别和临床免疫学特征

Sex and immunology characteristics in children with lupus nephritis

目的探讨儿童狼疮性肾炎的性别、临床和免疫学特征。方法将71例女性，6例男性红斑狼疮患者的临床、血清免疫学指标和肾脏损害进行比较。结果女性红斑狼疮患者关节炎、白细胞减少比男性常见，而男性盘状红斑较常见，且肾损害比女性严重。结论红斑狼疮临床表现、血清免疫学特征及发病率与性别有关，但男性狼疮性肾炎预后可能较差。

To investigate the sex and clinical immunology characteristics of lupus nephritis (LN) in children.Mether Clinical and serum immunological indexes of 71 female with systemic lupus erythematous (SLE) were reviewed and compared with those of 6 male counterparts.Results Artheritis and leukopenia were more common in female than male while discoid erythematous were more often seen in male. The renal injuries in male patients were more severe than those in female.Conclusion The clinical manifestation. serum immunological characteristics and incidence of SLE are associated with sex, but LN in males may have a worse prognosis.