应用氢呼气试验测定食物口-结肠转运时间

Determination of Food Oral colon Transit Time with Breath Hydrogen Test

目的建立测定食物口结肠转运时间（ＯＣＴＴ）的方法。方法采用氢呼气试验（ＢＨＴ），以乳果糖为对照，测定１３名健康成人对５组富含碳水化合物食物的口结肠转运时间。结果乳果糖糖浆９０．０ｍｉｎ±５０．６ｍｉｎ，红薯２３７．３ｍｉｎ±６４．９ｍｉｎ，馒头３４１．３ｍｉｎ±７７．９ｍｉｎ，玉米粉３５２．５ｍｉｎ±５９．５ｍｉｎ，大米组出现产氢人数少，肉末米饭组未出现氢值升高，故这两组均不能判断ＯＣＴＴ值；ＯＣＴＴ值与最高氢峰值呈负相关（ｒ＝－０．６６２５），与最高氢峰值出现的时间和吸收率呈正相关（ｒ分别是０７６６８和０．８７９０）。结论用氢呼气试验法测定食物的口结肠转运时间是简便、可靠、安全、可行的方法。

Objective To establish a method to determine food oral colon transit time (OCTT). Methods OCTT was determined for five groups of food rich in carbohydrate in 13 healthy adults with breath hydrogen test (BHT) using lactulose as control. Results OCTT was 90.0±50.6 min, 237±64.9 min, 341.3±77.9 min and 352.5±59.5 min, respectively for lactulose syrup, sweet potato, steamed bun and corn flour, and OCTT could not identified for rice and rice with ground meat due to hydrogen production only in few study subjects or no rising in hydrogen value. OCTT inversely correlated with peak hydrogen value ( r =-0 662 5) and correlated with the time of peak hydrogen value and food absorption rate ( r =0.766 8 and 0.879 0). Conclusion BHT is a simple, reliable, non invasive and feasible method to determine food OCTT.