摘要
目的探讨血清胱抑素C(CysC)与T2DM的关系及其在糖尿病肾病(DN)发生发展中的意义。方法选择140例T2DM(T2DM组)和30名正常对照(NC组),用放射免疫法测定尿白蛋白;用PENIA法测定血清CysC。结果 (1)T2DM组血清CysC浓度明显高于NC组。(2)血清CysC浓度在临床DN组明显高于单纯DM组。(3)血清CysC的AUC^(ROC)为0.898,与尿白蛋白排泄率的AUC^(ROC)相当,但明显优于血肌酐。结论血清CysC能够作为检测T2DM患者肾功能损害的指标。
Objective To investigate the relationship between serum cystatin C （Cys C） and type 2 diabetes mellitus（T2DM）. Methods The 140 patients diagnosed as T2DM were chosen as case group. The 30 normal individuals were as control group. Urine protein was measured with radioimmunoassay. Cys C was determined by particle-enhanced nephelometry immune assay （PENIA）. Results （1） As compared with control group, the serum cys C increased markedly in case group[-（0.85±0. 62） vs （0.45±0.08）mg/L]. （2） The serum cys C was significantly higher in CDN group than in SDM group [（1.45±0. 92） vs （0. 58±0. 17）mg/L]. （3） The study showed AUC^ROC of cys C was larger than that of Scr, and similar to that of UAER. Conclusions Cys C could be used as sensitive indicator for damage in kidney of type 2 diabetes.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2009年第8期613-615,共3页
Chinese Journal of Diabetes
