诺和锐30强化治疗对初诊2型糖尿病患者第一时相胰岛素分泌的影响

Effects of intensive insulin therapy by BIAsp30 on first-phase insulin secretion in newly diagnosed type 2 diabetics.

目的探讨短期诺和锐30强化治疗对初诊2型糖尿病(T2DM)患者第一时相胰岛素分泌缺陷的作用。方法对30例初诊T2DM患者进行每日3次诺和锐30强化治疗2周,治疗前后分别行静脉葡萄糖耐量实验,测定0、3、4、5、8、10、120分钟血糖、胰岛素及C肽值,计算胰岛素和C肽曲线下面积(AUC)及稳态模型胰岛素抵抗指数(HOMA-IR)。结果患者治疗后血清胰岛素及C肽第一时相分泌明显增加,AUC_(0～10min)均明显升高(P<0.01)。HOMA-IR指数明显降低(P<0.01)。结论短期每日3次诺和锐30强化治疗能明显改善初诊T2DM患者C肽的第一时相分泌及胰岛素敏感性。

Objective To explore the effects of transient intensive therapy with BIAsp30 on first-phase insulin secretion in newly diagnosed type 2 diabetics. Methods Thirty newly diagnosed T2DM patients were treated with thrice daily BIAsp30 for 2 weeks. Intravenous glucose tolerance tests （IVGTT） were performed before and after the treatments. During IVGTT, levels of blood glucose, insulin and C- peptide at 0,3,4,5,8,10, 120 minutes were measured. AUC of insulin and C-peptide were calculated. Remits After treatment, AUC0- 10min of insulin was increased from 64. 70±28. 18 mIU× min/L to 98. 2±32. 57mIU× min/L （P〈0. 01） and C-peptide from 4. 92± 1. 64nmol × min/L to 7. 09 ± 2.04nmol × min/L（P〈0. 01）. Furthermore, HOMA-IR index was decreased （ P 〈 0. 01 ）. Conclusions Thrice daily BIAsp30 intensive insulin therapy significantly improves the first-phase insulin secretion in newly diagnosed T2DM patients.