动脉粥样硬化性脑梗死与同型半胱氨酸、高敏C-反应蛋白的相关性分析

Analysis on relationship between high sensitivity c- reactive protein, homocysteine and atherothrombotic cerebral infarction

目的探讨和分析高敏C-反应蛋白、同型半胱氨酸与动脉粥样硬化性脑梗死的关系。方法选取114例动脉粥样硬化性脑梗死患者为试验组，同期选择年龄性别相匹配的健康体检者51例为对照组，测定血清C反应蛋白（C—reactive protein，CRP）及同型半胱氨酸（hornocysteine，HCY）水平，应用颈动脉彩色超声多普勒检查颈动脉粥样硬化斑块的大小及超声特点，同时通过测定患者颈动脉内膜中层厚度变化，常规法测定血脂指标。结果动脉粥样硬化性脑梗死患者血清高敏C反应蛋白、血浆同型半胱氨酸、甘油三酯、胆固醇、低密度脂蛋白均较对照组增高，差异有统计学意义（P〈0．05）；试验组颈动脉内膜中层增厚及2级以上斑块发生的例数多于对照组，差异有统计学意义（P〈0．05）。结论血清CRP及血浆HCY水平增高对反映动脉粥样硬化性脑梗死病变有显著临床意义。

Objective To investigate and analyze the relationship between high sensitivity C--reactive protein （hs-- CRP）, homocysteine （HCY） and atherothrombotic cerebral infarction. Methods One hundred and fourteen patients with atherothrombotic cerebral infarction were assigned as experimental group and fifty--one healthy people as control group. The levels of CRP and HCY were measured. The size of the plaques, the characteristic of carotid and the changes of carotid intimal--medial thickness （IMT） were examined by carotid duplex ultrasonography scanning. Total cholesterol （TC）, triglyceride （TG） and low--density lipoprotein （LDL） were measured routinely. Results The levels of serum hs-- CRP, plasma homocysteine, TC, TG, LDL were significantly increased in the experimental group compared to the control （P 〈 0.05）. Furthermore, the detection rates of higher carotid intimal--medial thickness and carotid plaque grade 2 or more were also significantly increased in the experimental group compared to the control （P〈 0.01）. Conclusions The elevated levels of CRP and HCY have significant indexes for the atherothrombotic cerebral infarction.