HLA-DQA1等位基因与原发性高血压的相关性研究

A STUDY OF CORRELATION BETWEEN ESSENTIAL HYPERTENSION AND HLA DQA1 ALLELES

目的对原发性高血压患者进行ＨＬＡ－ＤＱＡ１等位基因的分型，分析高血压病患者的遗传易感性。方法用ＰＣＲ－ＳＳＰ技术对具有遗传家族史的高血压病患者５２例及正常对照８６例，进行ＨＬＡ－ＤＱＡ１等位基因的基因分型。结果ＨＬＡ－ＤＱＡ１＊０３０２在高血压组的基因频率明显高于对照组（１７．９５７３对３．５５３１，Ｐ＜０．００１）。而ＨＬＡ－ＤＱＡ１＊０１０３却表现为正常组的增高。结论ＨＬＡ－ＤＱＡ１＊０３０２基因与高血压的遗传易感性相关联。

Objective To analyse the hereditary susceptibility by genotyping of HLA DQA1 alleles in essential hypertensives.Methods The allelic types of HLA DQA1 were detected by PCR SSP technic in 52 cases of essential hypertensives and 86 normal individials as the control.Results The frequency of HLA DQA1*0302 allele in hypertensive group was markedly higher than that in normal control group (17.9572 vs 3.5531), but the frequency of HLA DQA1*0103 allele in normal group was higher than that in hypertensive group. Conclusion HLA DQA1*0302 may be a correlative gene of essential hypertension, whereas HLA DQA1*0103 may be a defence gene of hypertension.