UPA在大肠癌中的表达及其与肿瘤侵袭的关系

Expression of UPA in Human Colorectal Cancer and Its Relation to Tumor Invasion

应用免疫组化技术（ＳＰ法）检测ＵＰＡ（ｕｒｏｋｉｎａｓｅｔｙｐｅｐｌａｓｍｉｎｏｇｅｎａｃｔｉｖａｔｏｒ）在５４例大肠癌组织中的表达，结果显示：３９例为ＵＰＡ阳性表达，阳性产物在细胞中的分布有三种类型：浆（浆膜）型、核型、混合型（胞浆、胞核），且在具有肌层侵袭、淋巴结转移的癌组织中阳性表达率分别高于无肌层侵袭、无淋巴结转移的癌组织（Ｐ＜０．０５），而其分化程度与ＵＰＡ的阳性表达无关（Ｐ＞０．０５），提示ＵＰＡ在大肠癌的侵袭和转移中可能起重要作用。

Using immunohistochemical technique (SP), expression of Urokinase type plasmirogen activator (UPA) in 54 human colorectal cancer tissues were determined. Thirty nine cases had positive UPA expression. The positive product in cells were divided into three types (the types of cytoplasm, nuclear and mixed). The positive expression of UPA in the cases with muscular layer invasion and lymph node involvement were significantly higher than those in cases without the above invasion ( P <0.05).There was no correlation found between the expression of UPA and differentiation of the tumor ( P >0.05). It indicates that UPA plays an important role in the invasion and metastasis of colorectal cancer.