丝裂霉素C白蛋白磁性微球用于裸鼠人肝癌模型疗效观察

Effects of Ferromagnetic Protein MMC bearing Microspheres on Human Liver Cancer Model in Nude Mice

观察了自制丝裂霉素Ｃ（ＭＭＣ）白蛋白磁性微球用于裸鼠人肝癌模型的疗效。结果显示：ＭＭＣ白蛋白磁性微球不仅是安全的，而且在体外磁场作用下可较长时间内沉积于靶区。分组试验显示：治疗组肿瘤体积缩小，与生理盐水对照组和ＭＭＣ对照组具有显著差异（第２、３周Ｐ＜０．０１，第１、４周Ｐ＜０．０５）；治疗组平均生存时间比上述两组对照组明显延长（Ｐ＜０．０５）。ＭＭＣ白蛋白磁性微球直接瘤内注射外加磁场的方法治疗裸鼠人肝癌模型有显著疗效。

The effects of ferromagnetic protein MMC bearing microsphere (FMS) were observed on human liver cancer model in nude mice. It was shown that the FMS was safe for experimental animals and it could deposit for quite a long time at the target area under the influence of magnetic field.Tumor growth was better inhibited in FMS group than in normal saline (NS) group and MMC group ( P <0.01 for the second and third week of treatment, P <0.05 for the first and fourth week). The mean survival period of FMS group ( 71.4 days) was prolonged compared to the control group of NS (38.0 days) and MMC group (56.4 days). It is concluded that the treatment by direct FMS injection into tumors under the guidance of an external magnetic field is significantly effective to the human liver cancer model in nude mice.