35例幼年类风湿性关节炎的预后及相关因素分析

Analysis of prognosis of juvenile rheumatoid arthritis and its correlation factors in 35 children

目的 :了解幼年类风湿性关节炎 (JRA)的预后 ,探讨影响 JRA预后的相关因素。方法 :分析临床资料并进行 7个月至 1 0年的随访 ,结果用χ2 检验。结果 :1 2 7/35例缓解 ,占 77.1 4% ,3例死亡 ,5例残疾。 2甲氨喋呤和金字塔方案治疗组 ,缓解率分别为 92 .86%及 53.85% (χ2 =5.34,P<0 .0 5)。 3发病后 6个月内和 6个月后进行正规治疗组 ,缓解率分别为 83.33%和 2 0 %(χ2 =8.99,P<0 .0 0 5)。缓解率与 JRA的发病年龄、性别和临床分型无明显的相关性 (P均 >0 .0 5)。结论 :患病初期 ,采用以甲氨喋呤为主的治疗 ,可使绝大部分

Objective:In order to study the prognosis and influence on its correlation factors in children with juvenile theumatoid arthritis (JRA).Methods:Clinical data were analyzed and follow up study from seven months to ten years was made.Results:①27/35 children with JRA were remitted (77.14%), 3/35 died,and 5/35 were deformited.②Therapeutic group with methotrexate (MTX) had better prognosis than group with pyramid,incidence of remission being 92 86% and 53.85% respectively ( χ 2 5.34, P <0 05).③Group of receiving therapy regularly within six months had better prognosis than that after six months,incidence of remission being 83.33% and 20% respectively ( χ 2 8.99, P <0 005).④The prognosis of JRA did not associate with the age of being ill,sex and clinical type of JRA ( P >0 05 totally).Conclusion:Most of children with JRA less than six months can be remitted by therapy with MTX.