放疗同时多因子介入治疗60例晚期癌症的随机研究

Radiotherapy combined with intervention treatment for patients with advanced cancer: a randomized study in 60 cases.

目的探索晚期癌症的治疗方法。方法１９９６年１月～１９９７年３月，将６０例预期生存仅３～６个月的晚期癌症患者随机分成两组：（１）综合治疗组：放疗的同时用化疗药物、免疫反应修饰剂和中药制剂等多因子介入治疗；（２）对照组：单用放疗。两组放疗方法相同，腹腔肿块照射ＤＴ５０Ｇｙ，２５次／３５天，其他肿块照射ＤＴ６０Ｇｙ，３０次／４２天。结果综合治疗组有效率、平均缓解期、中位生存期和１年生存率分别为９３．３％、７．４个月、１１个月和４６．７％，对照组分别为６３．３％、４．７个月、６．５个月和６．７％，两组差异均有显著性（Ｐ＜０．０１）。结论综合治疗可有效延长晚期癌症患者生存期，并明显改善其生存质量。

Objective To study methods of treatment for advanced cancers. Methods From January 1996 to March 1997, 60 patients with advanced cancers whose life expectancy was 3 6 months were randomly divided into two groups. The method of radiotherapy was the same in the two groups, with a dose of D T50Gy/25f/5wk for intra abdomanal cancers while D T60Gy/30f/6wk for those in the other regions. In the combination treatment group, in addition to radiation, interventional therapy with chemotherapeutic drugs, biological response modifiers or Chinese medicinal herbs was employed. Results The response rate, mean remission period, median survival time and 1 year survival rate in the combination treatment group was 98.3%, 7.4 months,11 months and 46.7%, respectively. All these were significantly different from those in the group of patients treated with radiation alone. (63.6%, 4.7 months, 6.5 months and 6.7%, respectively, P <0.01). Conclusion Radiotherapy combined with intervention treatment can prolong the survival time and improve quality of life in patients with advanced cancer.