胡蔓藤中非生物碱类化学成分的分离与鉴定

Isolation and identification of the non-alkaloid constituents from Gelsemium elegans Benth.

目的为进一步开发利用胡蔓藤（Gelsemium elegans Bentlx）中非生物碱类化学成分提供依据。方法采用HPD-800大孔吸附树脂色谱、硅胶柱色谱和ODS中压柱色谱分离，采用葡聚糖凝胶LH-20柱色谱及制备液相纯化，根据理化性质和波谱数据鉴定结构。结果分离鉴定了7个非生物碱类化合物，分别为东莨菪内酯（scopoletin，1）、咖啡酸乙酯（caffeic acid ethyl ester，2）、肉桂酸（cinnamic acid，3）、水杨酸（salicylic acid，4）、香草酸（vanillic acid，5）、白藜芦醇（resveratrol，6）、正三十六烷醇（hexatriacontan-1-ol，7）。结论化合物2-4、6为首次从胡蔓藤属植物中分离得到。

Objective To investigate the non-alkaloid constituents from the whole plant of Gelsemium elegans Benth. Methods Solvent extraction and column chromatography were used to isolate the non-alkaloid constituents, and physicochemical properties and spectroscopic analysis were employed for the determination of the structures. Results Seven compounds were isolated, and their structures were identified as scopoletin （ 1 ）, caffeic acid ethyl ester （2）, cinnamic acid （3）, salicylic acid （4）, vanillic acid （ 5 ）, resveratrol （ 6 ） and hexatriacontan-l-ol（7）. Conclusions Compounds 2-4 and 6 are obtained from this genus for the first time.