非酒精性脂肪肝患者血清视黄醇结合蛋白4的变化及意义

Change and clinical significance of serum retinoi-binding protein 4 level in patients with non-alcoholic fatty liver disease

目的研究非酒精性脂肪肝患者血清视黄醇结合蛋白4（RBP4）的变化及其与胰岛素抵抗（IR）的关系。方法采用ELISA法测定26例健康对照者及34例非酒精性脂肪肝患者血清RBP4水平。结果非酒精性脂肪肝患者血清RBP4水平[（25．6±11．2）mg／L]较健康对照者[（18．5±9．7）mg／L]明显升高，差异有统计学意义（P〈0．01）。相关分析显示RBP4与腰围、腰臀比、体重指数、总胆固醇、三酰甘油、空腹血糖、空腹血清胰岛素、稳态模型评估法胰岛素抵抗指数（HOMA-IR）有显著相关性（r=0．457、0．361、0．387、0．259、0．366、0．342、0．338、0．379，P〈0．01）。结论非酒精性脂肪肝患者血清RBP4水平升高，且与HOMA—IR呈正相关，提示RBP4在IR的发展中可能起一定的作用。

Objective To investigate the change and clinical significance of serum retinol-binding protein 4 （RBP4） level in patients with non-alcoholic fatty liver disease （NAFL）, and explore the correlation between RBP4 and insulin resistance（IR）. Method RBP4 levels were determined by ELISA in 26 normal controls （control group） and 34 NAFL patients （NAFL group）. Results Serum level of RBP4 in the NAFL group was significantly higher than that in control group [（25.6 ± 11.2） mg/L vs （18.5 ±9.7） mg/L, P 〈 0.01 ]. RBP4 was positively correlated with waistline, waist-to -hipratio, body mass index, total cholesterol, triglyceride, fasting plasma glucose, fasting insulin, HOMA-IR（r = 0.457, 0.361, 0.387, 0.259, 0.366, 0.342, 0.338,0.379, P 〈 0.01 ）. Conclusion Serum RBP4 levels are elevated in patients with NAFL and correlated with HOMA-IR, suggesting RBP4 may participate in the development of IR and NAFL.