肝性低氧血症与肺功能、一氧化氮和内皮素-1相关性研究

Study of the relationship between lung function,nitric oxide and endothelin -1 in hypoxemia of liver cirrhosis

目的探讨肝性低氧血症患者肺功能、一氧化氮、内皮素-1的变化情况及三者的作用和相互关系。方法测定60例肝硬化患者（肝硬化组）及30例健康人（对照组）肺功能、一氧化氮、内皮素-1及相关临床生化参数。结果肝硬化组一氧化氮水平明显高于对照组[分别为（86．74±32．49）、（52．46±8．77）μmol／L，P〈0．01]，内皮素-1水平则明显低于对照组[分别为（25．16±15．49）、（55．82±21．33）ng／L，P〈0．01]，肺功能指标均明显低于对照组（P〈0．01）。一氧化氮与内皮素-1呈负相关（r=-0．287，P=0．026），二者均与肝性低氧血症无相关性（P〉0．05）。结论肝性低氧血症在肝硬化早期肺功能即有改变，一氧化氮及内皮素-1虽共同参与肝硬化发展，但非促成肝性低氧血症的因素。

Objective To explore the relationship between lung function,nitric oxide （NO） and endothelin -1 （ET-1） in hypoxemia of liver cirrhosis. Method Lung function,NO, ET-1 and various clinical and biochemical parameter was detected in 60 patients with liver cirrhosis （liver cirrhosis group）and 30 healthy controls （normal control group）. Results The level of NO in liver cirrhosis group was significantly higher than that in normal control group [ （ 86.74 ± 32.49 ） μmol/L vs （52.46 ± 8.77 ）μmol/L, P 〈 0.01 ], but the level of ET-1 was significantly lower than that in normal control group [（25.16 ± 15.49） ng/L vs （55.82± 21.33 ） ng/L ,P 〈 0.01 ]. The lung function indexes in liver cirrhosis group were significantly lower than those in normal control group （P〈 0.01 ）. There was a negative correlation between NO and ET-1 （r = -0.287, P = 0.026 ）, and neither of them had a significant correlation with hypoxemia of liver cirrhosis （P 〉 0.05 ）. Conclusions Hypoxemia of liver cirrhosis occurs in the early stage of liver cirrhosis. NO and ET-1 are involved corporately in the development of liver cirrhosis, but not the main factors facilitating hypoxemia of liver cirrhosis.