胸腺类癌1例及文献复习

Thymic carcinoid:1 case report and review of literature

目的:探讨胸腺类癌的病理学特点及临床表现。方法:对1例胸腺类癌进行组织学表现、电镜和免疫组化染色观察及文献复习。结果:组织学特点:瘤细胞多排列为不规则巢状,条索状,伴有大量坏死,瘤细胞大小较一致,胞质弱嗜酸,颗粒状,边界不清,胞核呈圆形或椭圆。免疫组化特点:肿瘤细胞表达Syn(+)、CgA(+)、NSE(+)。电镜:部分瘤细胞及突起内见有神经内分泌颗粒。结论:胸腺类癌是前纵隔一种少见的恶性肿瘤,主要与胸腺瘤相鉴别,治疗以手术切除的疗效为最好。

Objective：To investigate the clinicopathologic and immunohistochemical characteristics of thymic carcinoid. Methods ： One case of thymic carcinoid was reported and the pathological features were studied by microscopy, immunohistochemistry and electron microscope. Results： The tumor was composed of monotonous ceils with the formation of nests, cords and ribbons and occasionally focal areas of necrosis. The tumor cells had abundant eosinophilic cytoplasm with a granular appearance and round to oval nuclei. The tumor cells showed positive staining for chromogranin, synaptophysin and neurone specific enolase. And neurosecretory granules can be observed on electron microscopy. Conclusion：Thymic carcinoid was a rare tumor of anterior mediastinum, mainly distinguished with thymoma, the best chance for a cure is complete surgical resection.