VEGFR1和MDR1在胃癌中的表达及意义

Expression of VEGFR1 and MDR1 in gastric cancer

目的:探讨VEGFR1和MDR1在胃癌中的表达及意义。方法:采用免疫组化SP法检测VEGFR1和MDR1在胃癌中的表达及与分化程度的关系;比较VEGFR1和MDR1在胃癌中的表达相关性。结果:VEGFR1在高、中、低度分化胃癌的表达率依次为15/53(28%)、19/43(44%)、37/54(68%);在低分化胃癌组织中的表达明显高于高分化和中分化胃癌组织(P<0.05)。MDR1在高、中、低度分化胃癌的表达率依次为18/53(34%)、21/43(48%)、41/54(76%);在低分化胃癌组织中的表达明显高于高分化和中分化胃癌组织(P<0.05)。结论:VEGFR1和MDR1在胃癌中的表达具有一致性,可能在胃癌的多药耐药中扮演重要角色。

Objective：To detect the expression of VEGFR1 and MDR1 in gastric cancer. Methods：Immunohistochemical analysis was used to detect the expression of VEGFR1 and MDR1 in gastric cancer and its relation with tumor type. Results ：VEGFR1 was positive in 71/150 （47 % ） cases of gastric cancer tissues,including 15/53 （28 % ） cases of well -differentiated tissues, 19/43 （44%） cases of moderate -differentiated tissues and 37/54 （68%） cases of poor - differentiated tissues. MDR1 was positive in 80/150（53% ） cases of gastric cancer tissues,including 18/53 （34%） cases of well - differentiated tissues ,21/43（48% ） cases of moderate - differentiated tissues and 41/54 （76%） cases of poor - differentiated tissues. Statistical analysis showed that there was significant correlation between the expression of VEGFR1 and MDR1 and the differentiation of gastric cancer. Conclusion： VEGFR1 and MDR1 might play important roles in the development of gastric cancer.