Ki-67在外周T细胞淋巴瘤-非特指型中的表达及意义

Significance of Ki-67 expression in nodal peripheral T-cell lymphama-unspecified

目的:探讨肿瘤增殖相关Ki-67表达与外周T细胞淋巴瘤-非特指型(PTCL-U)生物学行为的关系。方法:应用免疫组化法检测55例病理确诊PTCL-U患者Ki-67的表达情况,并分析与临床特征、治疗效果、预后的关系。结果:55例患者中Ki-67表达阳性率<20%,3例(5.5%);20%-39%:5例(9.1%);40%-59%:15例(27.3%);60%-79%:27例(49.1%);≥80%:5例(9.1%)。与预后指数、B症状、临床分期、一般行为状态成显著的正相关(均P<0.05),和首程化疗完全缓解呈显著的负相关(P=0.05)。Ki-67高表达(≥65%)组总生存率经LogRank检验显著低于低表达组(P=0.0002)。多因素生存分析显示Ki-67阳性表达率(P=0.023)和KIPI评分(P=0.044)是PTCL-U的独立不良预后因素。结论:Ki-67和KIPI能够预测PTCL-U对化疗的反应性和预后。

Objective ： To study the expression of Ki - 67 in peripheral T - cell lymphomas - unspecified （ PTCL - U）, and investigate the relationship between Ki -67 and PTCL -U＇s biological behavior. Methods： Fifty five patients with PTCL- U were detected for the expression of Ki -67 by immunohistochemistry and analysised the correlation with the PTCL- U＇s clinical feature, treatment effectiveness and prognosis. Results： 3 , 5 , 15, 27, 5 patients （ 5.5% ,9.1% ,27.3% ,49.1% ,9.1% ） were respectively positive for Ki - 67 expression 〈 20% ,20% - 39% ,40% - 59% ,60% - 79%, 〉180%. Exprssion of Ki - 67 was significantly positively correlated with IPI, B symptom, clinical stage, performance status （ P 〈 0.05 ）, negatively correlated with complete remission in first line treatment （ P = 0.036）. Overall survival rate of high Ki - 67 expression was significantly lower than that of low expression by Log - Rank test （ P = 0.0002 ）. Multivariate analysis showed higher Ki - 67 （ P = 0. 023 ） and KIPI（ P = 0.044 ） were inde- pendent poor prognostic factor for PTCL - U. Conclusion： Ki - 67 and KIPI can predict response of chemotherapy and prognosis in PTCL - U.