摘要
脉君安片是由葛根、氢氯噻嗪和钩藤三味药组成的复方制剂,临床用于高血压、冠心病等有较好的疗效。葛根素是葛根中的主要黄酮类化合物,对心脑血管疾病有显著的治疗作用[1]。氢氯噻嗪为中效利尿剂,它通过抑制肾小管对钠和水的再吸收,从而达到降压作用。
After oral administration of low, middle, high dose of simulative Maijunan tablets to SD rats and puerarin, hydrochlorothiazide at middle dosage to SD rats separately, plasma samples were collected at different times and treated with acetonitrile to precipitate protein. The contents of puerarin and hydrochlorothiazide in plasma were determined by HPLC method. The mean plasma concentration-time profiles of puerarin and hydrochlorothiazide at different dosages of medication administration were processed by 3P97 pharmacokinetic software and SPSS statistics 17.0 software. The results indicated that the in vivo kinetic processes of puerarin in rats were all fitted to a two-compartment open model and hydrochlorothiazide fitted to a one-compartment open model. Hydrochlorothiazide in vivo kinetic process in rats was in accordance with the linear dynamics. The combination of hydrochlorothiazide and rhynchophylla with pueraria promoted the absorption, reduced the elimination rate and prolonged the action time of puerarin in vivo. Meanwhile, the combination also promoted the absorption rate and the bioavailability, prolonged the action time and the accumulation time of hydrochlorothiazide in vivo.
出处
《药学学报》
CAS
CSCD
北大核心
2009年第9期1056-1060,共5页
Acta Pharmaceutica Sinica
基金
2008年湖北省高等学校优秀中青年团队计划项目(T200807)
关键词
葛根素
氢氯噻嗪
脉君安片
药动学
puerarin
hydrochlorothiazide
Maijunan tablet
pharmacokinetics