摘要
衰老的自由基假说强调了衰老过程中自由基的积累导致细胞损伤。阿尔茨海默病是多发于老年人的以认知和记忆功能障碍为特点的神经退行性疾病。衰老是阿尔茨海默病的关键危险因素。大量证据表明,机体自由基生成和清除平衡的破坏是促进衰老和神经退行性改变的主要原因。脑组织通过诱导一系列基因的表达对抗氧化应激,这些基因被称作生命基因。生命基因的表达产物主要包括热休克蛋白家族、血红素加氧酶系统和硫氧还蛋白系统,他们构成了机体内源性的防御系统。本文综述了生命基因在衰老和阿尔茨海默病脑组织中的表达和功能,以及相关药理学研究。
Free radical hypothesis of aging emphasized that the age-related accumulation of free radicals results in cell injury. Alzheimer＇s disease （AD） is the most common form of neurodegenerative disease characterized by impaired cognition and memory of the elderly. Aging is a key risk factor in AD. Substantial evidence suggests that imbalance between free radical formation and clearance promotes AD pathogenesis. The brain overcomes oxidative stress by inducing expression of a set of genes called vitagenes. The protein products of vitagenes include heat shock proteins, heme oxygenases and thioredoxin systems, which serve as endogenous lifeguard of cells. This paper is a review of the expression and function of vitagenes in aging and AD brain, as well as relevant pharmacological study.
出处
《药学学报》
CAS
CSCD
北大核心
2009年第8期825-832,共8页
Acta Pharmaceutica Sinica
基金
国家重点基础研究发展计划(973计划)资助项目(2007CB507400)
