8-异前列腺素F2α与高血压及阻塞性睡眠呼吸暂停低通气综合征

Relationship between 8-iso-prostaglandin F2α, hypertension and obstructive sleep apnea-hypopea syndrome

8-异前列腺素F2α（8-iso—prostaglandin F2α，8-iso—PGF2α）是机体内脂质过氧化反应的特异性产物，是评价氧化应激和脂质过氧化反应理想的生物学指标。阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea—hypopnea syndrome，OSAHS）是一种常见的睡眠呼吸紊乱疾病，常并发高血压病。8iso—PGF2α不仅能敏感反映OSAHS的氧化应激状态，并可能为OSAHS并发高血压的预测因子，现就8-iso—PGF2α与高血压及OSAHS的相关性作一综述。

8-iso-prostaglandin F2α （8-iso-PGF2α ） which is a specific product of the lipid peroxidation,is an index to appraise the oxidative stress and lipid peroxidization ideal biology target. Obstructive sleep apneahypopnea syndrome（OSAHS） is a common disease of disordered breathing, with higher risk of developing hypertention. Studies show that 8-iso-PGF2α can be not only as an evaluation of OSAHS patients with oxidative stress in a sensitive indicator, also may be a predictor of hypertension in OSAHS patients. The review is about the relationship between 8-iso-PGF2α ,hypertension and OSAHS.