泌尿生殖道支原体感染检测及抗菌药物的分析

Detection and Susceptibility to Antibiotics of Mycoplasma in Genitourinary Tract

目的了解泌尿生殖道支原体感染情况及药物敏感性,指导临床合理应用抗菌药物。方法应用法国生物梅里埃公司提供的IST试剂盒进行支原体鉴定和9种药物的敏感检测,并对结果进行分析。结果382例患者中检出支原体阳性共171例,总感染率为44.8%,其中解脲脲支原体(Uu)单独感染率为69.6%,人支原体(Mh)单独感染率为2.9%,Uu+Mh感染率为8.8%,低滴度Uu+Mh感染率为18.7%,总敏感率最高的是普那霉素86.5%,交沙霉素84.8%,总敏感率最低的是环丙沙星26.3%。结论支原体感染以Uu单独感染为主,对常用抗菌药物的耐药性已很严重,临床应选用培养敏感的抗菌药物,以提高治疗效果。

OBJECTIVE To investigate the infection status and antibiotic susceptibility of Mycoplasrna in our area, so as to instruct the rational use of antibiotics. METHODS Genitourinary secretions were colIected with swabs. They were cultured with the diagnostic kit of Mycoplasma （Biomerieux Company）. Meanwhile the susceptibility of Mycoplasma against 9 antimicrobial agents was tested with the same kit. According to the instrnction of the kit, the results were read. The data were statistically analyzed. RESULTS A total of 382 samples were collected, and the positive rate was 44.8%. which were composed by Uu 69.6%, Mh2.9%, and Uu＋ Mh infection 8. 8% and low titer Uu＋ Mh infection 18. 7%. The result of drug sensitivity showed that sensitivity of Mycoplasrna to pristinamycin PRI, 86.5% was the highest, then was to JOS （84.8%） and CIP （26.3%）. CONCLUSIONS Ureaplasma urealyticum is the major cause of infection in genitourinary system. It shows serious resistance to commonly used antibiotics. Sensitive antibiotics should be selected based on the results of bacterial culture and drug sensitivity tests so as to raise the clinical curative effects.