老年颅内外动脉硬化分布特点的研究

Clinical study of distribution characteristics of extracranialintracranial arterial sclerosis in the elderly

目的观察老年人群中颅内外动脉硬化分布特点。方法随机选择年龄≥65岁的老年患者2115例,根据数字减影血管造影术和CT血管造影结果,将患者分颅内外动脉硬化组(硬化组,311例)和无颅内外动脉硬化组(无硬化组,1804例)。分析其动脉硬化分布特点。结果与无硬化组比较,硬化组体重指数(22.7±4.4vs26.4±3.1)、高血压(18.5%vs47.9%),糖尿病(7.9%vs38.3%)和高尿酸血症(5.8%vs15.8%)均明显升高,差异显著(P<0.01);颅内外动脉硬化好发于颈内动脉颅外段(39.9%);轻度狭窄患者明显高于中度和重度狭窄患者,差异显著(P<0.01)。结论颅内外动脉硬化和好发部位及狭窄程度有较强的规律性,探讨颅内外动脉硬化特点对神经介入治疗有指导作用。

Objectives To investigate the characteristics of distribution of extracranial-intracranial arterial sclerosis in the elderly. Methods 2 115 participants,aged 65 years old or over,were randomly selected from the inpatients and outpatients in our hospital. All participants were screened by digital subtraction angiography（DSA） and CT angiography（CTA）,and were divided into with extracranial-intracranial arterial sclerosis group（311 patients） and group without extracranial-intracranial arterial sclerosis（1 804 patients） based on the result of imaging examination. Results Compared with subjects without extracranial-intracranial arterial sclerosis, those with extracranial-intracranial arterial sclerosis had higher BMI （P 〈 0.01） ,higher systolic blood pressure and diastolic blood pressure （P 〈 0.01） ,higher fasting plasma glucose,triglyceride and uric acid （P〈 0. 01）. Extracranial-intracranial arterial sclerosis more frequently happened in the extracranial segment of internal carotid artery（39.9%）. Conclusions Study of characteristics of extracranial- intracranial arterial sclerosis is important to neurological intervention and treatment of cerebral infarction.