血管活性物质在重症急性胰腺炎合并心脏损伤时的变化

The changes of vasoactive substances in severe acute pancreatitis complicated with cardiac injury in rats

目的探讨前列环素(PGI2)、血栓素(TXA2)、内皮素(ET)、一氧化氮(NO)在重症急性胰腺炎(SAP)合并心脏损伤时的作用。方法将54只SD大鼠随机分为6组,每组9只;分别为假手术2、6、12h组,SPA2、6、12h组。建立大鼠SAP合并心脏损伤动物模型,检测淀粉酶(AMY)、脂肪酶(LIP)、肌酸肌酶(CK)、乳酸脱氢酸(LDH)、羟丁酸脱氢酶(LBDH)、PGI2、TXA2、ET、NO含量,心脏病理形态变化。结果SAP组血浆AMY、LIP、CK、LDH、LBDH、TXA2/PGI2、ET、NO含量与假手术组比较差异有统计学意义(P<0.01)。结论ET、NO、TXA2/PGI2可能是介导SAP合并心脏损伤的重要介质。

Objective To investigate the role of PGI2, TXA2, ET, NO in severe acute pancreatitis （SAP） complicated with cardiac injury in rats. Methods 54 SD rats were randomly divided into 6 groups （ n = 9 in each group）,sham operation 2h,6h, 12h groups;SPA 2h,6h, 12h groups. The models of SAP complicated with cardiac injury in rats were established, and the serum levels of AMY, LIP, CK, LDH, LBDH, PGI2, TXA2, ET and NO were detected, and the pathological morphological changes were observed. Results There were significant differences in the serum levels of AMY, LIP, CK, LDH, LBDH, TXA2/PGI2, ET, NO between SAP groups and sham operation groups （ P 〈 0.01 ）. Conclusion The ET, NO,TXA2/PGI2 may be the important mediums that result in SAP complicated with cardiac injury.