血管紧张素1型受体基因多态性及饮食、行为因素与新疆哈萨克族高血压的关系

Relationship study of angiotensin II type 1 receptor gene Al166C polymorphism, food consumption and behavior on hypertension in Kazakh group, Xinjiang

目的探讨血管紧张素Ⅱ1型受体（AT1R）基因A1166C多态性及环境因素与新疆哈萨克族高血压的关系。方法以现况调查的哈萨克族人群为基础，应用SPSS13．0软件中的随机数字表，在确诊的高血压患者中随机抽取220例为高血压组，血压正常者220名为对照组，进行问卷调查及相关指标测量，应用聚合酶链反应法检测基因型。结果（1）高血压组中，AA和AC两种基因型的频率分别为78．6％（173／220）、21．4％（47／220），对照组中基因型的频率分别为81．4％（179／220）、18．6％（41／220），差异无统计学意义（χ^2=0．537，P〉0．05）。高血压组中A和C两种等位基因频率分别为89．0％、11．0％，对照组中分别为90．3％、9．7％，差异无统计学意义（χ^2=0．37，P〉0．05）。（2）AC基因型与口味偏咸（高血压组31／220、15．5％，对照组10／220、4．5％，OR：4．67，95％CI：2．15—10．15）、肥胖（高血压组19／220、8．6％，对照组9／220、4．1％，OR：6．96，95％CI：2．33—20．76）、大量饮用奶茶（高血压组20／220、9．1％，对照组10／220、4．5％，OR：2．67，95％CI：1．11～6．42）发生交互作用，可提高具有该基因型人群的高血压患病危险性。结论AT1R基因A1166C多态性与哈萨克族高血压发生无关。具有AC基因型的哈萨克族人群可能与饮食、行为因素发生交互作用，增加个体患高血压的危险度。

Objective To investigate the polymorphism of angiotensin Ⅱ type 1 receptor （ AT1 R） gene Al166C and environmental factors on hypertension of Kazakh people. Methods Through the random program of SPSS 13.0,220 cases were randomly selected from the confirmed hypertension patients, and 220 cases with normal blood pressure were selected as control group. All cases were investigated through the questionnaire and the related indexes were measured. By polymerase chain reaction （PCR） method, the genotypes were determined. Results （ 1 ） In hypertension group, the genotype frequency of AA and AC were 78. 6% （173/220） and 21.4% （47/220） ,respectively ,compared with control groups＇ 81.4% （179/220） and 18. 6% （41/220）, no significant difference was identified between these two groups （ χ^2 = 0. 537, P 〉 0. 05）. In hypertension group, the frequency of A and C allele were 89. 0% and 11.0%, respectively, compared with 90. 3% and 9. 7% in control group. There was no significant difference between these two groups （χ^2 = 0. 37, P 〉 0. 05 ）. （2） AC genotype might interact with excessive salt consumption （ hypertension group, 31/220,15.5 % ; control group 10/220,4. 5 % , OR ： 4. 67,95 % CI： 2. 15 - 10. 15 ） , overweight （hypertension group,19/220,8.6% ; control group,9/220,4. 1% ,OR： 6. 96,95% CI： 2. 33 - 20.76 ） and drinking large volume of salty milk （ hypertension group ,20/220,9. 1% ; control group, 10/220, 4. 5% ,OR： 2. 67,95% CI： 1.11 -6.42） which will raise hypertension hazard of AC genotype. Conclusion There is no relationship between the A1166C gene polymorphism of AT1R gene and hypertension of Kazakh people. AC genotypes might also interact with food consumption habit and behavior factors and increase the individual risk of hypertension.