Ang-2、MMP-2在乳腺癌中的表达及意义

The significance of Ang-2 and MMP-2 expressions in breast cancer

目的探讨Ang-2、MMP-2表达与乳腺癌临床病理特征的关系,分析二者表达的相关性。方法采用免疫组化SABC法检测46例乳腺浸润性导管癌和10例乳腺纤维腺瘤组织中Ang-2、MMP-2的表达水平。结果46例乳腺癌组织中Ang-2、MMP-2表达阳性率分别为56.5%、73.9%,高于乳腺纤维腺瘤。Ang-2、MMP-2的表达水平与乳腺癌组织学分级显著相关;腋窝淋巴结转移组Ang-2、MMP-2表达阳性率高于无转移组。Ang-2、MMP-2的表达相互之间显著相关。结论乳腺癌组织中Ang-2、MMP-2表达上调,在乳腺癌发生、发展过程中具有重要作用。Ang-2、MMP-2协同刺激乳腺癌血管生成,可能是促进乳腺癌发生转移的重要机制。Ang-2可能成为判断乳腺癌预后的重要指标。

Objective： To investigate the expressions of Ang-2 and MMP-2 in breast cancer and its correlations with clinicopathological characteristics, and to analyze the association of Ang-2 and MMP-2 in breast cancer. Methods ： Expressions of Ang-2 and MMP-2 in 46 breast invasive ductal carcinoma and 10 breast fibroadenoma spicemens were detected by immunohistochemical method （SABC）. Results： Ang-2 and MMP-2 positive expression rates were 56.5% and 73.9% in 46 breast carcinomas respectively, which were significantly higher than those in breast fibroadenomas. In high histological grade diseases Ang-2 and MMP-2 positive rates were significantly higher than those in low grade diseases. Ang-2 and MMP- 2 positive expressions were associated with axillary lymph node metastases. Significant correlations were found between Ang-2 and MMP-2 expressions. Conclusion： Ang-2 and MMP-2 over-expressions in breast caicinoma are significantly corre- lated with occurrence, development of breast cancer. Ang-2, MMP-2 cooperate in promoting the vascular growth of breast cancer. Ang-2 might serve as a valuable prognostic indicator in breast cancer.