复方芎蝎胶囊治疗椎基底动脉供血不足的疗效观察

Clinical effect of vertebrobasilar ischemia treated by Compounds Xiong-Xie capsule

目的观察复方芎蝎胶囊治疗椎基底动脉供血不足(VBI)的疗效和对脑血流的影响。方法将60例VBI患者随机分为2组。对照组30例予注射用盐酸川芎嗪120 mg加入0.9%氯化钠注射液250 mL,每日1次静脉滴注。治疗组30例在对照组治疗基础上加用复方芎蝎胶囊2.5 g,每日3次口服。2组均15 d为1个疗程,疗程间休息1周,2个疗程后统计临床疗效,经颅多普勒(TCD)探测椎动脉(VA)、基底动脉(BA)收缩峰流速(Vp)和舒张末期流速(Vd)。结果治疗组痊愈率83.3%,总有效率96.7%,对照组痊愈率60.0%,总有效率86.7%,2组总有效率、痊愈率比较差异均有统计学意义(P<0.05);2组VA、BA的Vp和Vd治疗后与本组治疗前比较均有不同程度的提高(P<0.05),且2组治疗后比较差异均有统计学意义(P<0.05),治疗组优于对照组。结论复方芎蝎胶囊是治疗椎基底动脉供血不足的有效药物。

Objective To observe the effect to vertebrobasilar ischemia （VBI） and influence of cerebral blood flow （CBF） treated by Compounds Xiong - Xie capsule. Methods The 60 cases of VBI were randomly divided into 2 groups. Patients in control group （ n = 30） were treated by 120mg Ligustrazine added in 0.9% NS 250 mL iv gtt/d. 30 cases in treatment group were treated by Compounds Xiong- Xie capsule, 2.5g ,3/d PO, under the basis of control group＇treatment. The therapeutic course in both groups were 15 d, and then the curative effect were compared on two groups after two courses of treatment by the TCD of VA, BA, VP and VD. Results The cure rate and total effective rate in treatment group （83.3% , 96.7% ） were higher than those in control group （60.0%, 86. 7%, P 〈 O. 05 ）. Conclusion Compounds Xiong - Xie capsule has definite effect on the treatment of vertebrobasilar ischemia.