R-四氢噻唑-2-硫酮-4-羧酸同R.S-氨基醇的手性识别反应

Chiral Recognition Reaction of Rthiazolidine2thione4carboxylic Acid with R.Saminoalcohols

Ｒ－四氢噻唑－２－硫酮－４－羧酸同Ｒ．Ｓ－亮氨醇、Ｒ．Ｓ－蛋氨醇、Ｒ．Ｓ－苯丙氨醇和Ｒ．Ｓ－色氨醇反应分别得到光学活性非对映体过剩的铵盐：Ｒ－四氢噻唑－２－硫酮－４－羧酸·Ｓ－亮氨醇、Ｒ－四氢噻唑－２－硫酮－４－羧酸·Ｒ－蛋氨醇、Ｒ－四氢噻唑－２－硫酮－４－羧酸·Ｒ－苯丙氨醇和Ｒ－四氢噻唑－２－硫酮－４－羧酸·Ｓ－色氨醇，同时分离出光学活性对映体过剩的Ｒ－亮氨醇、Ｓ－蛋氨醇、Ｓ－苯丙氨醇及Ｒ－色氨醇。用半经验的量子化学ＰＭ３方法研究了氨基醇的最优构型和电子结构，得到了铵盐的最优几何构型。

The optical activity diasteroisomeric excess ammonium salts Rthiazolidine2thione4carboxylic acid·Sleucinol, Rthiazolidine2thione4carboxylic acid·Rmethioninol, Rthiazolidine2thione4carboxylic acid·Rphenylalaninol and Rthiazolidine2thione4carboxylic acid·Stryptophanol were prepared by the reaction of Rthiazolidine2thione4carboxylic acid with corresponding R.Saminoalcohol. At the same time the optical activity enantiomeric excess Rleucinol, Smethioninol, Sphenylalaninol and Rtryptophanol were separated. The electronic structure and optimized configuration of the aminoalcohols have been studied by molecular orbital PM3 method, the optimized configuration of optical activity ammonium salts were obtained.