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急性脑梗死患者血红素氧合酶-1、非结合胆红素含量动态变化及临床意义

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摘要 氧自由基的增加及其脂质过氧化损伤是脑缺血损伤的主要途径之一,是引起缺血性后继发脑损伤的一个重要因素。近年来研究表明在应急状态下血红素氧合酶-1(HO-1)可作为保护性蛋白被诱导,以防御体内由细胞因子介导的凋亡,有良好的抗脑缺血损伤作用。
出处 《浙江医学》 CAS 2009年第7期997-998,1019,共3页 Zhejiang Medical Journal
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参考文献6

  • 1Bhaskaran M,Reddy K,Radhakrishnan N,et al.Angiotensin Ⅱ induces apoptsis in renal proximal tubular cells[J].Am Physiol Renal Physiol,2003,284(5):955-965.
  • 2符荣,赵甲山,赵洪洋,朱贤立,陈衔城.一氧化碳及一氧化氮对局灶性缺血脑组织的影响[J].中风与神经疾病杂志,2004,21(1):36-38. 被引量:7
  • 3Regan R F,Rogers B.Delayed treatment of hemoglobin neurotoxicity[J].J Neurotrauma,2003,20(2):111-120.
  • 4Shokawa T,Yoshizumi M.Yamamoto H,et al.Induction of heme oxygenase-1 inhibits monocyte chemoacttratant protein-1 mRNA expression in U937 cells[J].J Pharmacol sci,2006,100(3):162-166.
  • 5Taille C,El-Benna J,Lanone S,et al.Induction of heme oxygenase-1 inhibits NADPH oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability[J].J Biol Chem,2004,279(27):28681-28688.
  • 6Soares M P,Seldon M P,Gregoire L P,et al.Heme oxygenase-1 modulates the expression of adhesion associated with endothelial cell activation[J].J Immunol,2004,172(6):3553-3563.

二级参考文献15

  • 1Dawson DA. Nitric oxide and focal cerebral ischemia:multiplicity of action and diverse outcome[J]. Cerebrovasc Brain Metab Rev, 1994,6 (4): 299-324.
  • 2Xie QW, Leung M, Fuorates M,et al. Completmentation analysis of mutants of nitric oxide synthase reveals that the active site requires two heme[J]. Proc Natl Acad Sci USA,1996,93:4891-4896.
  • 3Kutty RK,Maines MD. Effects of induction of heme oxygenase by cobalt and tin in the in vivo degradation of myoglobin[J].Biochem Pharmacol, 1984,18: 2924-2926.
  • 4White KA,Marletta MA. Nitric oxide synthase is a cytochrome p-4540 type hemoprotein [J]. Biochemistry, 1992, 31: 6627-6631.
  • 5Weiss G,Werner-Felmayer G, Werner ER,et al. Iron regulates NO synthase activity by controlling nuclear transcription[J]. J Exp Med, 1994,180: 969-976.
  • 6Baranano DE,Snyder SH. Neural role for heme oxygenase:contrasts to nitric oxide[J]. Proc Natl Acad Sci USA,2001,98:10996-11002.
  • 7Chalmers AN. Simple,sensitive measurement of carbon monoxide in plasma[J]. Clin Chem, 1991,37(8): 1442-1445.
  • 8Green LC,Wagner DA,Glogowski J,et al. Analysis of nitrate, nitrite and N-nitratein biological fluids[J]. Anal Biochem, 1982,126:131.
  • 9Maine MD. The heme oxygenase system:a regulator of second messenger gases[J]. Annu Rev Phamacol Toxicol, 1997,37: 517-554.
  • 10Maine MD. Carbon monoxide:an emerging regulator of cGMP in the brain[J]. Mol Cell Neurosci, 1993,4: 389-397.

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