期刊文献+

解偶联蛋白2的作用研究进展

下载PDF
导出
摘要 解偶联蛋白(UCPs)属于一类载体蛋白,位于线粒体内膜上。目前发现有5个同系物,包括UCP1~UCP5。它们通过介导线粒体内膜的“质子漏”,使能量以热的形式散失。现已发现,它们有很多共同的特点,但其表达的主要组织和主要作用均不同。UCP2mRNA广泛存在于骨骼肌、心肌、胎盘、肝脏、脾脏、胰腺、肾脏、肺、胃和小肠等组织及中枢神经系统内,尤其在白色脂肪组织中呈高度表达;
出处 《浙江医学》 CAS 2009年第7期1034-1035,共2页 Zhejiang Medical Journal
  • 相关文献

参考文献2

二级参考文献9

  • 1穆里斯KB 朱立煌等(译).聚合酶链式反应[M].北京:科学出版社,1997.17-20.
  • 2Fleury C, Neverova M, Collins S, et al. Uncoupling protein -2:a novel gene linked to obesity and hyperinsulinemia. Nature Gen, 1997, 15:269--272.
  • 3Gong DW, He Y, Karas M, et al. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, (3-adrenergic agonistic, and leptin. J Biol Chem, 1997,272:24129--24132.
  • 4Matsuda J, Hosoda K, Itoh H, et al. Cloning of rat uncoupling-3 and uncoupling-2 cDNAs: their gene expression in rats fed high-fat diet.FEBS Lett, 1997,418:200--204.
  • 5Oherkofler H, Liu YM, Esterbauer H, et al. Uncoupling protein-2 gene reduced mRNA expression in intraperitoneal adipose tissue of obese human. Diabetologia, 1998,41:940-946.
  • 6Nicholls DG, Locke RM. Thermogeneic mechanisms in brown fat. Physol Rev, 1984,64:1--64.
  • 7Strosberg AD, Pietri-Rouxel F. Role of thermogensis in the regulation of energy balance in relation to obesity. J Physiol Pharmacol, 1998,67:394--401.
  • 8P. G. Cassell,M. Neverova,S. Janmohamed,N. Uwakwe,A. Qureshi,M. I. McCarthy,P. J. Saker,L. Albon,P. Kopelman,K. Noonan,J. Easlick,A. Ramachandran,C. Snehalatha,C. Pecqueur,D. Ricquier,C. Warden,G. A. Hitman. An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes[J] 1999,Diabetologia(6):688~692
  • 9S. A. Urhammer,L. T. Dalgaard,T. I. A. S?rensen,A. M. M?ller,T. Andersen,A. Tybj?rg-Hansen,T. Hansen,J. O. Clausen,H. Vestergaard,O. Pedersen. Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: Impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance[J] 1997,Diabetologia(10):1227~1230

共引文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部