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关于癌变细胞红外光谱测定方法的研究 被引量:6

Determination of Canceration Cells With Fourier Transform Infrared Spectrometry
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摘要 利用博里叶变换红外光谱(FTIR)高分辨手段,对正常人的细胞和千余名宫颈癌患者的细胞进行了对比研究,初步得出此方法能在分子水平上揭示出肿瘤细胞与正常细胞的明显差别,并且通谱图解析,可直接阐明引起谱图变化的主要原因、细胞癌变的可能机理,从而对病程进行预测,为肿瘤疾病的早期诊断展现了良好的前景。 A new method for the determination of the canceration cells has been proposed. By means of the high resolution of Fourier transform infrared spectrometry, we have conducted the comparison and study on the normal human cells and those of more than l000 patients suffering from the cervical carcinoma. It has concluded preliminarily that this method can explain the obvious difference between the cancer cells and the normal ones from the molecular level. Morever, through the interpretation of the spectra, it can explain directly the main reasons causing the change of the spectra, the possible mechanism of the cells canceration and thus the course of the illness can be forcasted and a bright future for diagnosing cancer in early stage is developed.
出处 《分析化学》 SCIE EI CAS CSCD 北大核心 1998年第7期883-885,共3页 Chinese Journal of Analytical Chemistry
关键词 宫颈癌 癌变细胞 测定 癌症 FTIR 诊断 Fourier transform infrared spectrometry, cervical carcinoma, canceration cell
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  • 1慈云祥,高体玉,董建强,阚秀,郭振泉.乳腺良、恶性组织中蛋白质二级结构的Fourier变换红外光谱研究[J].科学通报,1999,44(17):1861-1866. 被引量:10
  • 2孙传文,徐怡庄,孙开华,吴奇光,李维红,许振华,吴瑾光.中红外光纤技术用于腮腺肿瘤诊断的研究[J].光谱学与光谱分析,1996,16(5):22-25. 被引量:30
  • 3张志超,袁翠,万谦宏.磁性二氧化硅微球的表面修饰及其在植物基因组核酸纯化中的应用[J].分析化学,2007,35(1):31-36. 被引量:24
  • 4[7]Soloway RD,Xiaofeng Ling,Weihong Li,et al.Human Malignant and benign gastric mucosal operative specimens demonstrate differences using fourier transform infrared fiberoptic and fluorescence spectroscopies.Gastroenterology,1999,116,A508.
  • 5[8]Weihong Li,Xiaofeng Ling,Yizhuang Xu,et al.Infrared spectra of normal and malignant tissues:establishment of a database.Gastroenterology,2000,118:A1397.
  • 6[9]Rigas B,Morgello S,Goldman IS,et al.Human colorectal cancers display abnormal Fourier-transform infrared spectra.Proc.Natl Acad USA,1990,87:8140-8144.
  • 7[10]Rigas B,Wong PTT.Human colon adenocarcinoma cell lines display infrared spectroscopic features of malignant colon tissues.Cancer Research,1992,52:84-88.
  • 8[11]Wong PTT,Wong RK,Caputo T,et al.IR spectroscopy exfoliated cervical cells:Evidence of extensive structural changes during carcinogenesis.Proc Natl Acad Sci USA,1991,88:10988-10992.
  • 9[13]Fung MFK,Senterman M,Eid P,et al.Comparison of Fourier-Transform Infrared Spectroscopic Screening of Exfoloiated Cervical Cell with Standard Papanicolaou Screening.Gynecologic Oncology,1997,66:10-15.
  • 10[14]Malins DC,Polissar NL,Nishikida K,et al.The etiology and prediction of breast cancer.Fourier transform-infrared spectroscopy reveals progressive alterations in breast DNA leading to a cancer-like phenotype in a high proportion of normal women.Cancer,1995,75:503-517.

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