端粒重复序列结合因子1在非小细胞肺癌中的表达及其临床意义

Expression and clinical significance of telomeric repeat binding factor 1 in non- small cell lung carcinoma

目的探讨人端粒重复序列结合因子1（TRF1）在非小细胞肺癌（NSCLC）肺组织中的表达及其与临床、病理的关系。方法采用Envision免疫组织化学染色法检测40例NSCLC患者手术切除后石蜡包埋标本和37例癌旁正常肺组织中TRF1的表达水平，并分析其与NSCLC患者临床、病理指标及生存期的关系。结果NSCLC组织中TRF1蛋白阳性表达率显著高于癌旁正常组织（P〈0.01）；TRF1蛋白在NSCLC组织中的阳性表达水平与患者性别、年龄、是否长期吸烟、肿瘤大小、淋巴结是否转移、病理TNM分期、分化程度、组织学类型和总生存期等方面的差异均无统计学意义（均P〉0.05）。结论TRF1在NSCLC组织中的阳性表达率明显高于癌旁正常组织，但其表达水平则与NSCLC的组织学类型、性别、年龄、是否长期吸烟、肿瘤大小、淋巴结是否转移、病理TNM分期、分化程度及预后无关。

Objective To investigate the expression of telomeric repeat binding factor 1 in NSCLC and it＇s relationship with clinicopathological features. Methods Expressions of TRF1 were detected by immunohistochemical method （EnVision methods） in 40 paraffin-embeded samples from surgically resected non-small cell lung carcinomas and 37 normal tissue at side of cancer. Relationship between clinicopathologic characteristic, survival and expressions of TRF1 was analyzed. Results Positive TRF1 expression rate in NSCLC was significantly higher than normal tissue at side of cancer（P〈0.01）,the positive expression of TRF1 in NSCLC is no statistical differencein groupes divided by gender, age,long-term smoking, tumor size, lymphonode involvement, pathological TNM stages, differentiated degree and overall survival （P〉0.05）. Conclusion Positive TRF1 expression rate in NSCLC was significantly higher than normal tissue at side of cancer.The expression of TRF1 in NSCLC is not related with histology type, gender, age,long-term smoking, tumor size , lymphonode involvement, pathological TNM stages, differentiated degree and prognosis.