蛋白激酶C神经保护作用的研究进展

Research Progress of Protein Kinase C in Neuroprotection

蛋白激酶C属于丝氨酸/苏氨酸激酶家族成员,在各种生命现象中发挥着重要的作用。它调控细胞整个生长周期,表达异常会对神经细胞造成毒性,甚至导致细胞凋亡。本文介绍蛋白激酶C在调控神经细胞增殖与凋亡、发挥神经细胞损伤保护及抑制神经毒性中的作用,进一步探讨其可能的分子作用机制,为了解蛋白激酶C在神经系统疾病中的作用提供参考。

Protein Kinase C （PKC） belong to serine/threonine kinase family members, play significant role in different vital phenomena. It can control the whole growth cycle of the cell the express abnormality can cause toxicity to the nerve cell, even result in apoptosis. This paper introduce the function of PKC in controlling nerve cell growth cycle, protecting nerve cells and inhibiting nerve cell toxicity, explore further the possible molecular mechanism, provide the reference to understand the PKC in the nervous system disease.