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髓样细胞触发受体1在炎性反应中的作用 被引量：2

Role of Triggering Receptor Expressed on Myeloid Cells-1 in Inflammatory Response
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摘要 髓样细胞触发受体1(TREM-1)是一种在炎性反应的触发及放大过程中具有重要作用的蛋白。TREM-1选择性表达于血液中性粒细胞和单核/巨噬细胞表面,通过与跨膜蛋白DAP12的信号转导系统偶联发挥作用,可放大促炎性细胞因子的释放,因此在感染性疾病、脓毒症、急性胰腺炎等免疫相关疾病的发病中均发挥着重要作用。针对TREM-1进行干预可能为相关疾病提供新的治疗途径。 Triggering receptor expressed on myeloid cells-1（TREM-1） which is expressed on the surface of neutrophils and monocytes/macrophages plays an important role in the activation and amplification of inflammatory response. TREM-1 ,couples to the activation protein of 12 kDa （ DAP12） ,can amplify the release of proinflammatory cytokines, thus play important roles in many immune correlated liseases such as infectious diseases ,sepsis and acute pancreatitis. Interfering in TREM-1 will be a new treatment to relevant diseases.
作者 梁志海 唐国都
机构地区 广西医科大学第一附属医院消化内科
出处 《医学综述》 2009年第18期2747-2749,共3页 Medical Recapitulate
关键词 髓样细胞触发受体1 炎症 脓毒症 急性胰腺炎 Triggering receptor expressed on myeloid cells-1 Inflammatory Sepsis Acute pancreatitis
分类号 R364.5 [医药卫生—病理学]
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共引文献40

同被引文献18

  • 1邵洁,黄新文,孙眉月,杜立中,汤永民,乐园罗.新生儿败血症外周血中性粒细胞CD_(64)的表达及其意义[J].中华儿科杂志,2005,43(7):510-513. 被引量：24
  • 2闵安杰,杨兴华,张自功,马铮铮,周捷,黄晓元.TREM-1在脆弱类杆菌脂多糖诱导单核细胞炎症反应中的作用[J].中华外科杂志,2007,45(9):630-631. 被引量：3
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医学综述
2009年 第18期

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