Claudins整合膜蛋白研究进展

Research Progress of Claudins Integral Membrane Proteins

Claudins整合膜蛋白为细胞间紧密连接的主要成分,在调节生物体内各区间溶质流以及维持内稳态平衡中发挥重要功能。Claudins对上皮或内皮细胞间黏附、极性发育、上皮增生的微环境和屏障功能的调控发挥重要作用,其变化直接影响细胞旁屏障渗透性,与肿瘤、炎症、遗传疾病、病毒感染、细菌毒素等多种临床疾病的发生密切相关。

Claudins are important integral membrane protein components of tight junctions （TJs）, which have pivotal functions for regulation of paracellular permeability and homeostasis of ions and solutes. Claudins are critical proteins for various biological functions such as intercellular adhesion of epithelium and endothelium, polarity development, microenvironment for cell proliferation, polarity, and regulation of barrier function. Changes in the expression levels of claudins affect paracellular permeability ,which is involved in tumorigenesis, inflammation, hereditary disease, viral infection and bacterial toxins.