肺癌治疗性疫苗的临床应用进展

Clinical Development of Therapeutic Vaccine for Lung Cancer

肿瘤疫苗即是利用肿瘤细胞或肿瘤抗原物质诱导机体的特异性细胞免疫和体液免疫反应,以调节机体免疫功能,达到治疗肿瘤的目的。治疗性肿瘤疫苗可通过主动免疫诱导全身特异性抗肿瘤效应。根据其制备方法不同,疫苗主要分为:细胞疫苗、多肽疫苗和蛋白质疫苗、核酸疫苗、抗独特型抗体疫苗等。本文对目前肺癌相关疫苗的类型、研究进展和临床应用情况进行综述,从而为进一步的研究提供一定的借鉴和参考。

Tumor vaccine is the use of tumor cells or tumor antigen to induce the specific cellular immunity and humoral immunity to regulate immune function, and achieve the purpose of treatment tumors. Therapeutic tumor vaccine can induce the specific anti-tumor effect of the whole body by active immunization. According to the different preparation methods, tumor vaccine is divided into：cell vaccines, peptide and protein vaccines, nucleic acids vaccine, anti-idiotypic antibody vaccine et al. This article reviewed the type of lung cancer vaccine, research progress and clinical application,so as to provide a further reference to the future research.