期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肾缺血再灌注损伤及其保护的研究进展 被引量：18

Research Development of Renal Ischemia Reperfusion Injury and Its Protective Strategies
下载PDF
导出
摘要 缺血再灌注损伤是急性肾衰竭的常见原因,也是肾脏移植术后影响移植物早期功能恢复和长期存活的主要因素之一。本文综述了肾缺血再灌注损伤的机制以及内源性和外源性防治肾缺血再灌注损伤的机制研究概况。 Ischemia-repedusion injury is a common cause of acute renal failure and the major factor limiting the function and survival of the transplanted kidney. This article summarized the mechanistic studies on renal ischemia-reperfusion injury and clinical and laboratory explorations of protective strategies against it.
作者 石旦 何小舟 徐海燕 夏萤
机构地区 苏州大学第三临床医学院 美国耶鲁大学医学院
出处 《医学综述》 2009年第18期2802-2806,共5页 Medical Recapitulate
关键词 肾缺血再灌注损伤 保护 预处理 Renal ischemia-reperfusion injury Protection Preconditioning
分类号 R692 [医药卫生—泌尿科学] R743.33 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献26

  • 1Iniquez M,Dotor J,Feijoo E,et al.Novel pharmacologic strategies to protect the liver from ischemia-reperfusion injury[J].Rec Pat Card Drug Discov,2008,3(1):9-18.
  • 2Christophe M,Nicolas S.Mitochondria:a target for neuroprotective interventions in cerebral ischemia-reperfusion[J].Curr Pharm Des,2006,12(6):739-757.
  • 3Baatscheer A,Schumacher CA,et al.Increased Na+/H+-exchange activity is the cause of[Na+]I and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model[J].Cardiovascular Research,2003,57(4):1015-1024.
  • 4Fomin VV.Ischemic renal disease:clinico-pathogenetic features,diagnostics,treatment[J].Klin Med,2008,86(4):8-14.
  • 5Toronyi E.Role of apoptosis in the kidney after reperfusion[J].Orv Hetil,2008,149(7):305-315.
  • 6Leslie JA,Meldrum KK.The role of interleukin-18 in renal injury[J].J Surg Res,2008,145(1):170-175.
  • 7Kher A,Meldrum KK,Wang M,et al.Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury[J].Cardiovasc Res,2005,67(4):594-603.
  • 8Huang Y,Rabb H,Womer KL.Ischemia-reperfusion and immediate T cell responses[J].Cell Immunol,2007,248(1):4-11.
  • 9Caldwell CC,Schoep JT,Lentsch AB,et al.Lymphocyte function during hepatic ischemia/reperfusion injury[J].J Leukoc Biol,2007,30(2):274-276.
  • 10Turnberg D,Botto M.CD59a deficiency exacerbates ischemia-reperfusion injury in mice[J].Am J Pathol,2004,165(3):825-832.

二级参考文献20

  • 1冷静,彭韬,冯振卿,钱玲梅,王笑云.大鼠肾缺血再灌注后肾小管上皮细胞凋亡的研究[J].江苏医药,1998,24(12):865-867. 被引量：5
  • 2龚华渠,杨天德,陶军.高渗盐水对缺血再灌注损伤肾组织髓质过氧化酶活性的影响[J].重庆医学,2006,35(6):519-520. 被引量：3
  • 3Rizoli SB,Kapus A,Fan J,et al.Immunomodulatory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagec shock[J].J Immunol,1998,161(11):6288
  • 4Oreopoulos GD,Hamilton J,Rizli SB,et al.In vivo and in vitro modulation of intercellular adhesion molecule (ICAM)-1 expression by hypertonicity[J].Shock,2000,14(3):409
  • 5Zahler S,Kupatt C,Becker BF,et al.Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-а[J].FASEB J,2000,14(3):555
  • 6Hamid R,Carmelo C,Mendiola S,et al.Antibodies to ICAM-1 protect kidneys in severe ischemic reperfusion injury[J].Biochem Biophys Res Communi,1995,211(1):67
  • 7Kelly KJ,Williams WW,Colvin RB,et al.Intercellular adhesion molecule-1deficient mice are protected against ischemic renal injury[J].J Clin Invest,1996,15(2):97
  • 8Lee HT, Emala CW. Protective effects of renal ischemic preconditioning and adenosine pretreatment: role of A (!) and A(3) receptors. Am J Physiol Renal Physiol, 2000, 278(3):380.
  • 9Gray MO, Zhou HZ, Schafhalter-Zoppoth I, et al. Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon.J Biol Chem, 2004, 279(5):3596-3604.
  • 10Kazuro S , Su Zhi , Li Fenghua , et al . Gender influences [Ca^2+]i during metabolic inhibition in myocytes overexpressing the Na^+-Ca^2+ exchanger. Circulation, 2001, 104(17) :2101-2106.

共引文献4

同被引文献155

引证文献18

二级引证文献67

医学综述
2009年 第18期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部