TNF-α在重症肺炎心力衰竭中的作用研究

The study on effect of TNF α in patients with severe pneumonia with heart failure

目的探讨TNF-α在重症肺炎心力衰竭中的作用。方法选择30例重症肺炎并心力衰竭患者作为心衰组,30例非重症肺炎患者作为肺炎组,30例健康儿童作为健康组,分别测定血清TNF-α和CK-MB的含量。结果肺炎组和心衰组的TNF-α和CK-MB浓度均较健康组升高(P<0.05),而心衰组的TNF-a和CK-MB浓度又较肺炎组升高(P<0.05),心衰组TNF-α与CK-MB之间呈正相关。结论当重症肺炎并心力衰竭时,TNF-α可显著升高,引起患者的心肌损害,最终导致心衰。

Objective To explore the effect of TNF α in heart failure caused by severe pneumonia. Methods Choose 30 cases of patients with severe pneumonia and heart failure as the group of heart failure, 30 cases of patients with severe pneumonia as the group of severe pneumonia, 30 cases of healthy children as the group of common, and measure the contents of the serum TNF α and CK MB. Results The concentrations of serum TNF-α, and CK-MB in the group of severe pneumonia and the group of heart failure were significantly higher than group of common（P〈0.05）, while the concentrations in the group of heart failure were higher than the group of pneumonia （P〈0.05）, and in the group with heart failure TNF a is positively correlative with CK MB. Conclusion The level of TNF-α increases in patients with heart failure caused by severe pneumonia.