老年慢性阻塞性肺病患者血清甲状腺激素水平的临床观察

Study on serum levels of thyroid hormone in senile patients with chronic obstructive pulmonary disease

目的探讨老年慢性阻塞性肺疾病(COPD)患者血清甲状腺激素水平的变化及其临床意义。方法选择40例急性加重期及稳定期老年COPD患者为研究对象,30例年龄匹配的健康体检者为对照组。应用化学发光免疫分析法测定血清甲状腺激素(TT3、TT4、FT3、FT4)及促甲状腺激素(TSH)水平,并测定动脉血气分析水平。结果COPD急性加重期患者血清TT3水平显著低于稳定期患者及对照组,缓解期患者TT3水平与对照组比较差异无显著性意义。急性加重期患者TT3与PaO2呈正相关。结论老年COPD急性加重期患者血清TT3水平低于同年龄健康对照组,测定血清TT3水平对COPD患者病情判断及其预后估计具有一定临床参考价值。

Objective To investigate the alteration and clinical significance of serum thyroid hormone levels in senile patients with chronic obstructive pulmonary disease （COPD）. Methods The contents of serum thyroid hormone（total thyroxine, TT4; total triiodothyronine, TT3; free triiodothyronine, FT3; free thyroxine, FT4）and thyroid stimulating hormone （TSH） for forty senile patients with COPD, either in the acute exacerbation phase or stable phase, and thirty age-matched healthy subjects were detected in the method of chemiluminescence immunoassay. At the same time, the blood gas analysis of aterial blood was also determined. Results The difference of serum TT3 between cases of COPD in acute exacerbation phase and controls had a statistical significance（P〈0.05）, while that in the stable phase and controls didn＇t（P〉0. 05）. Besides, TT3 was positively correlated with PaO2 in the acute exacerbation phase of COPD patients （P〈0.05）. Conclusions Compared with age-matched normal controls, the serum TT3 levels in patients of senile COPD with acute exacerbation were significantly lower, which might be valuable for determining the condition and predicting the pronosis.