维生素K_1与肝素治疗慢性阻塞性肺疾病的疗效观察

An observation of vitamin K1 united heparin's treatment effect to chronic obstructive pulmonary disease

目的探索维生素K1联合肝素对慢性阻塞性肺疾病急性加重期的治疗作用。方法筛选45例慢性阻塞性肺疾病按序分成两组，治疗组22例，维生素K10．5～1mg／Kg，最大剂量50mg，加普通肝素100U／kg，最大剂量5000U，取代氨茶碱和其他＆肾上腺素受体激动荆和糖皮质激素气管啧雾荆药物；对照组23倒，用常规氨茶碱＋糖皮质激素喷雾剂呼吸道吸入。两组其他抗茵、消炎、化痰药不变，治疗组无须用止咳药。结果两天后治疗组心率减慢，运动耐量明显改善，痰液明显减少，咳嗽明显减轻。而对照组两天后心率无减慢，运动耐量无明显改善。两组心率、运动耐量经X2检验（P〈0．01），差异有显著性。结论维生素K1联合肝素通过其解痉、改善血液循环、抗炎作用，对慢性阻塞性肺疾病急性加重期的呼吸频率、心率和运动耐量缓解作用明显，尤其是对心肺功能不全患者更有益处。

Objective This paper is intended to explore the treatment effect of Vitamin K 1 united Heparin to Chronic obstructive pulmonary disease （COPD） in the acute exacerbation period, point out the meaning of improving Mi- crocirculation. Methods We divide 45 choosen cases of COPD into two groups, and the treatment group consists of 22 cases. We use Vitamin K 1 （0. 5-1mg/Kg to the maximum dose 50mg） and Heparin（100U/kg to the maximum dose 5000U） to replace aminophylline, other β2 adrenergic receptor agonists and tracheal spray glueoeorticoid drugs. The control group, consisting of 23 cases, takes conventional aminophylline and eorticosteroid sprays through respiratory inhalation with the same other anti bacterial, anti inflammatory and expectorant as the treatment group. And there is no need to use cough medicine to the treatment group. Results Two days after the treatment group＇s heart rates are reduced, exercise tolerance obviously improved, sputum significantly reduced and cough relieved. In contrast, Two days after there is no heart rates reduction and obvious exercise tolerance improvement happening to the control group. Two sets of heart rates, exercise tolerance tested by X2 , P value 〈0.01. There is significant difference. Conclusion Vitamin K 1 United heparin through its spasmolytie, improving blood circulation and anti inflammatory, have obviously alleviate effect on the respiratory rates, heart rates and exercise tolerance of COPD in the acute exacerbation period, especially beneficial for pa- tients with cardiopulmonary dysfunction.