异甘草酸镁治疗化疗药物性肝损害疗效观察

Effect of magnesium isoglycyrrhizinate in the treatment of the hepatotoxicity caused by anti-tumor agents in cancer patients

目的观察异甘草酸镁对于恶性肿瘤患者接受化疗时并发药物性肝损害的治疗作用。方法将化疗后出现药物性肝损害56例患者分为2组,治疗组(28例)予以异甘草酸镁注射液;对照组(28例)予以甘草酸二铵注射液,观察比较两组患者治疗肝损害的疗效,1次/d,连用2周。结果2周后,两组丙氨酸氨基转移酶、天门冬酸氨基转移酶及总胆红素较治疗前均明显下降(P<0.01),两组之间无显著性差异(P>0.05),但显效率治疗组(71.43%)明显高于对照组(42.86%)(P<0.05)。结论异甘草酸镁对恶性肿瘤患者化疗药物性肝损害有较好的治疗作用。

Aim To explore an effective therapy for medicamentous liver lesion induced by chemotherapy in cancer patients. Methods A total of 56 patients with malignant tumor complicated with medicamentous liver lesion induced by chemotherapy were randomly assigned to receive magnesium isoglycyrrhizinate（ treatment group）or diammonium glycyrrhizinate for injection（ control group）iv gtt qd for 2 con- secutive weeks. Results After the treatment for 2 weeks,levels of alanine aminotransferase（ ALT）, aspartate aminotransferase（AST） and total bilirubin （TB）decreased in both groups（ P 〈 O. 01 ）, but there was no significant difference between two groups （P 〉 0.05 ）. The rate of marked improvement（71.43% in treatment group and 42.86% in control group）was a significant difference（P 〈 O. 05 ）. Conclusion MgIG is effective in the treatment of the hepatotoxicity caused by chemotherapy in patients with malignant tumors.