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Structure-based design,synthesis of novel inhibitors of Mycobacterium tuberculosis FabH as potential anti-tuberculosis agents 被引量:1

Structure-based design,synthesis of novel inhibitors of Mycobacterium tuberculosis FabH as potential anti-tuberculosis agents
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摘要 Mycobacterium tuberculosis FabH, an essential enzyme in mycolic acids biosynthetic pathway, is an attractive target for novel anti-tuberculosis agents. Structure-based design, synthesis of novel inhibitors of mtFabH was reported in this paper. A novel scaffold structure was designed, and 12 candidate compounds that displayed favorable binding with the active site were identified and synthesized. 2009 Song Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. Mycobacterium tuberculosis FabH, an essential enzyme in mycolic acids biosynthetic pathway, is an attractive target for novel anti-tuberculosis agents. Structure-based design, synthesis of novel inhibitors of mtFabH was reported in this paper. A novel scaffold structure was designed, and 12 candidate compounds that displayed favorable binding with the active site were identified and synthesized. 2009 Song Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第9期1019-1022,共4页 中国化学快报(英文版)
基金 supported by the National Basic Research Program of China(No.2004CB518908) the National High Technology Research and Development Program of China(No.2006AA020601)
关键词 Structure-based design SYNTHESIS Enzyme inhibitor Mycobacterium tuberculosis FabH Structure-based design Synthesis Enzyme inhibitor Mycobacterium tuberculosis FabH
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