摘要
An efficient synthesis of benzoxazole-substituted 3,4-dihydropyrimidinones (DHPMs) using trifluoro acetic acid as the catalyst for the first time from an aldehyde, 13-keto ester and benzoxazole-substituted urea/thiourea under solvent-free conditions is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields (80-91%) and short reaction time (40-130 min) at reflux temperature. 2009 M. Adharvana Chad. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
An efficient synthesis of benzoxazole-substituted 3,4-dihydropyrimidinones (DHPMs) using trifluoro acetic acid as the catalyst for the first time from an aldehyde, 13-keto ester and benzoxazole-substituted urea/thiourea under solvent-free conditions is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields (80-91%) and short reaction time (40-130 min) at reflux temperature. 2009 M. Adharvana Chad. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.