2型糖尿病认知障碍患者的中医证候聚类分析

Cluster analysis on traditional Chinese medicine syndrome of type 2 diabetes mellitus patients with cognitive impairment

目的应用变量聚类分析的数理统计方法，对2型糖尿病认知障碍进行中医分型。方法收集153例2型糖尿病认知障碍患者，记录患者中医症状、体征、舌象和脉象等临床资料。对临床资料进行变量聚类分析。结果116个变量聚类分4类的情况更加符合临床实际；解释比例为71．26％。2型糖尿病认知障碍在调查群体中分为精髓亏虚、痰瘀互阻、肝郁化热和脾肾两虚4型，解释比例分别为36．29％、27．53％、19．01％和17．17％。结论2型糖尿病认知障碍的中医证候以精髓亏虚，痰瘀互阻为主。变量聚类分析能够帮助2型糖尿病认知障碍中医证候的合理分型。

Objective To analyze the traditional Chinese medicine （TCM） syndrome of type 2 diabetes mellitus （DM） patients with cognitive impairment by variable cluster statistical analysis. Methods One hundred and fifty-three patients with type 2 DM cognitive impairment were collected, and their clinical symptoms, tongue and pulse signs were recorded. Then the patients＇ clinical data were analyzed by cluster analysis. Results These patients could be divided into four types of TCM syndrome （71.26%）： marrow deficiency, phlegm and blood stasis, liver-qi stasis and spleen and kidney deficiency types. The variable proportion was 36.29%, 27. 53%, 19.01%, 17.17%. Conclusion The types of TCM syndrome in type 2 DM cognitive impairment mainly include marrow deficiency and/or phlegm and blood stasis. And the way of variable cluster analysis may help the TCM syndrome differentiation in patients with type 2 DM cognitive impairment.