高压氧联合依达拉奉和尼莫地平治疗重度急性一氧化碳中毒的临床分析

Curative effect of hyperbaric oxygen combined with edaravone and nimodipine on severe acute carbon monoxide poisoning

目的探讨高压氧联合依达拉奉和尼莫地平治疗重度急性一氧化碳（CO）中毒的疗效。方法将60例重度急性CO中毒患者随机分为对照组和治疗组各30例，对照组予以高压氧、甘露醇、纳洛酮、胞二磷胆碱等治疗；治疗组在对照组治疗的基础上加用依达拉奉30mg静脉点滴2次／d，尼莫地平30mg3次／d，疗程均为14d。结果治疗组平均昏迷时间（3．54±1．62）h，对照组平均昏迷时间（6．52±2．08）h，治疗组明显短于对照组（P〈0．05）；治疗组有效率96．6％，对照组有效率73．3％，治疗组明显高于对照组（P〈0．05）；治疗组迟发性脑病6．9％，对照组迟发性脑病36．4％，治疗组明显低于对照组（P〈0．05）。结论高压氧联合依达拉奉和尼奠地平治疗重度急性CO中毒疗效显著。

Objective To explore the curative effect of hyperbaric oxygen （HO） combined with edaravone and nimodipine on severe acute carbon monoxide poisoning. Methods 60 cases of severe acute carbon monoxide poisoning were randomly divided into the control group （ n = 30 ） and the treatment group （ n = 30 ）. Patients in both groups were given hyperbaric oxygen, mannitol, naloxone and CDPC. Patients in treatment group also received edaravone injection （30 mg） twice per day and nimodipine 30 mg three times per day for 14 days. Results Average time of coma in treatment group was （3.54 ± 1.62 ） h, which was significantly shorter than （ 6. 52 ± 2.08 ） h in control group （ P 〈 0.05） ; the effective rate （96. 6% ） in treatment group was significantly higher than 73.3% in control group （ P 〈 0.05 ） ; the incidence of delayed encephalopathy （ 6. 9% ） after acute carbon monoxide poisoning in treatment group was significantly lower than 36. 4% in control group （ P 〈 0. 05 ） . Conclusion The apparent curative effect is observed in the patients with severe acute carbon monoxide poisoning by the use of hyperbaric oxygen combined with edaravone and nimodipine.