卡普氯铵及其结构类似物的合成

Synthesis of Carpronium Chloride and Its Analogue

γ-丁内酯和氯化亚砜经开环、氯代得4-氯丁酰氯,再与甲醇或乙醇经酯化得4-氯丁酸甲酯或乙酯,与三甲胺水溶液在强碱性阴离子树脂和碘化钾作用下经季铵化、纯化后得卡普氯铵及其乙酯类似物,总收率分别为88.4%和78.2%。

Carpronium chloride was synthesized from 7-butyrolactone by ring-opening and chlorination to give 4-chlorobutyryl chloride, which was subjected to esterification and quaterisation using alkali anion resin and KI as catalyst in an overall yield of 88.4 %. Its ethyl ester analogue was prepared by the same way with an overall yield of 78.2 %.