社区获得性肺炎左氧氟沙星序贯疗法的临床评价与成本效果分析

Observation on therapeutic effect of sequential therapy with levofloxacin on community acquired pneumonia

目的探讨左氧氟沙星序贯疗法治疗社区获得性肺炎的疗效。方法将社区获得性肺炎有效病例134例分为序贯治疗组（68例）和对照组（66例），序贯治疗组采用左氧氟沙星序贯疗法，对照组采用静脉滴注疗法。结果2组治愈率比较无显著性差异（P〉0．05），序贯治疗组治疗费用、不良反应均明显低于对照组（P〈0．01或0．05）。结论左氧氟沙星序贯疗法治疗社区获得性肺炎疗效确切，可缩短住院时间，降低医疗费用，减少不良反应发生，使患者依从性提高，是治疗社区获得性肺炎的理想疗法。

Objective To evaluate the efficacy of sequential treatment of levofloxacin on community acquired pneumonia. Methods 134 patients with community acquired pneumonia were divided into levofloxacin group（ n = 68 ） and control group（ n = 66） treated with Cefuroxime. The 68 inpatients with CAP in our hospital were treated with levofloxaein 400 mg a day of intravenous for 3 to 4 days, then changed to oral administration for 7 to 11 days. The 66 controls received levofloxaein intravenously for 11 days. Results There was no significant difference in efficacy rate between these two groups;there were less adverse reactions and lower costs in levofloxacin group. Conclusion Levofloxaein may be offered as an alternative to clinicians for treatment of community acquired pneumonia. Sequential therapy of levofloxa- cin for community acquired pneumonia was reliable and save the patients, money and shorten their hospital stays.