硫酸普拉酮钠用于足月妊娠促宫颈成熟的临床观察(附60例报告)

EFFECT OF SODIUM PRASTERONE SULFATE ON CERVICAL RIPENING IN TERM PREGNANCY (REPORT OF 60 CASES)

目的：研究硫酸普拉酮钠促宫颈成熟作用的临床价值。方法：选择１２０例足月妊娠宫颈未成熟或未完全成熟的孕产妇，随机分为两组，每组６０例，观察组应用硫酸普拉酮钠，对照组应用苯甲酸雌二醇，对比观察两组宫颈Ｂｉｓｈｏｐ评分、产程进展、产后出血、新生儿Ａｐｇａｒ评分。结果：观察组促宫颈成熟有效率明显增高（Ｐ＜０．０５），第一产程活跃期缩短（Ｐ＜０．０５）；两组产妇出血量及新生儿Ａｐｇａｒ评分无明显差异（Ｐ＞０．０５）。结论：硫酸普拉酮钠是一种安全、有效的促宫颈成熟剂。

Objective:To explore the cervical ripening effect of sodium prasterone sulfate(SPS).Methods:The cervical ripening effect of SPS was studied in comparison with that of estradiol benzoate(EB). 120 cases of term pregnancy women were divided into two groups.Sixty cases were treated with sodium prasterone sulfate and the other sixty cases were treated with estradiol benzoate.Cervical ripening,course of labor,post partum hemorrhage and neonatal Apgar scores were observed.Results:The statistically significant difference of cervical ripening and course of labor existed between the two groups.The cervical Bishop's scores of SPS group is higher than that of the EB group (P< 0.05 ),the course of labor of SPS group is shorter than that of EB group (P< 0.05 ).No significant differences in the hemorrhage of post partum and neonatal Apgar score were found between the two groups.Conclusion:SPS is effective and safe to cervical ripening.