摘要
目的探讨CD4+CD25+调节性T细胞(Treg细胞)在晚期肺癌中的表达及其临床意义。方法应用流式细胞术分析30例晚期肺癌患者外周血CD4+CD25+Treg细胞表达水平,与10例健康人比较。结果晚期肺癌患者外周血CD4+CD25+Treg细胞数量增加(17.9±6.1)%,表达高于正常人(6.81±0.4)%(P<0.001)。肺癌患者外周血中Treg细胞数量与患者的病理类型无关(P>0.05),但与临床分期和组织学分化程度有关(P<0.01)。结论Treg细胞在肺癌患者中比率明显升高,并与临床进展有关。
Objective To explore the changes of CD4^＋ CD25^＋ regulatory T（Treg） cells in patients with advanced lung cancer and its significance. Methods The frequency of CD4^＋ CD25^＋ Treg cells in peripheral blood of 30 patients with lung cancer and 10 healthy controls was determined by flow cytometry. Results CD4^＋ CD25 ^＋ Treg cells numbers were significantly more in 30 patients with lung cancer（17.9 ±6. 1）% than that in 10 healthy donors（6.81 ± 0. 4）% （P 〈 0. 001） . The level of CD4 ^＋ CD25 ^＋ Treg cells was correlated with clinical stage and pathological differentiation （ P 〈 0. 01 ）, but not with pathological classification （P 〉 0. 05 ）. Conclusion The proportion of CD4^＋ CD25 ^＋ Treg cells in peripheral blood of patients with advanced lung cancer was significantly increased, and they may play an essential role in the development of advanced lung cancer.
出处
《医药论坛杂志》
2009年第16期8-9,共2页
Journal of Medical Forum
