肝素抑制后发性白内障的病理研究

A Pathological Study of Inhibition of Secondary Cataract with Heparin

家兔行晶体囊外摘除并人工晶体植入术,皮质冲吸液中含肝素100U/ml。术后不同的时间分别摘除眼球,用光镜、电镜和放射自显影方法观察眼内组织的变化。发现用肝素后眼内组织的炎症及纤维蛋白沉着较对照组轻,后囊细胞增生较不活跃。结论认为肝素可能"推迟"上皮细胞向成纤维样细胞的转化。

Extracapsular lens extraction and posterior chamber lens implantation were performed in 14 albino rabbits and heparin (100U/ml) was contained in irrigating solution during the operation.After operation,the eyes were enucleated at different intervals and observed with light microscope,electron microscope and autoradiography.It was found that inflammatory infiltration and fibrin deposit was less in heparinized eyes than those in control eyes,and that fibroblast like cells on posterior capsule were much thinner in heparinized eyes than those in control eyes.It was thought heparin might 'delay' the proliferation and metaplasia of the epithelial cell to fibroblast-like cell in anterior capsule.