烧伤患者心理应激对T淋巴细胞反应的影响

The Effect of Psychological Stress on T Lymphocyte Response in Burn Patients

以22例小面积烧伤患者为研究对象,通过 CES-D 抑郁量表的筛选,将患者分为烧伤伴抑郁症状组(A 组)和烧伤无抑郁症状组(B 组),并对两组患者进行汉密顿抑郁量表(HAMD)评分、血浆β-内啡肽(BEP)和淋转功能检测。结果表明,A 组的 HAMD 评分及血浆 BEP 水平较 B 组明显升高,而 A 组的淋转功能则明显低于 B 组。患者的 HAMD 评分与血浆 BEP 水平存在显著的正相关,而血浆 BEP 水平则与淋转功能呈显著的负相关。研究提示,烧伤病人的抑郁症状作为心理应激的一种表现形式,对淋巴细胞功能有抑制作用。

A controlled study was carried out in 22 hospitalized patients with mild burns in order to establish the relationship between the depressive disorder,the psychological stress and the lymphocyte function after burn injury.The patients were divided into two groups,the burns with depressive disorder (group A) and the burns without depressive disorder (group B) according to their CES-D scale examinations.We examined the patients HAMD (Hamilton depression scale) scores, plasma β-endorphin levels and lymphocyte responses to PHA.The results showed that in group A, the HAMD scores and the plasma β-endorphin levels were obviously increased and the lymphocyte responses to PHA were decreased significantly as compared to the group B.Furthermore,there was a positive correlation between HAMD scores and plasma β-endorphin levels.The plasma β-endorphin levels was also found to be negatively correlated to the lymphocyte responses to PHA.The findings suggest that during the hospitalization,depressive disorder of burn patients is a kind of psycological stress which could inhibit their lymphocyte functions.